2-amino-6-fluoro-N-methylbenzamide → Diethyl (4-{[4-{[3-fluoro-2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

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Reaction Steps

The title compound was prepared according to the procedure from Example 102 (Diethyl (4-{[4-{[4-fluoro-2-(methylcarbamoyl)-phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate) using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 2-amino-6-fluoro-N-methylbenzamide (Compound 155A). 1H NMR (DMSO-d6, 400 MHz): δ=1.19 (t, J=7.07 Hz, 6H), 2.76 (d, J=4.80 Hz, 3H), 3.19-3.27 (m, 2H), 3.76 (s, 3H), 3.93-4.02 (m, 4H), 6.78-6.83 (m, 1H), 6.97-7.03 (m, 2H), 7.38 (d, J=7.07 Hz, 1H), 7.49 (d, J=6.82 Hz, 1H), 8.00 (br. s., 1H), 8.38 (s, 1H), 8.62 (d, J=3.79 Hz, 1H), 8.80 (br. s., 1H), 9.78 (s, 1H). MS (ES+): m/z 586.14 [MH+] (TOF, polar).

Provenance & Evidence