HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-fluoro-N-methylbenzamide → 2-amino-6-fluoro-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-fluoro-N-methylbenzamide | HCID 43132558 | — |
| Reactant | 2-fluoro-N-methyl-6-nitrobenzamide | HCID 67255708 | — |
| Product | 2-amino-6-fluoro-N-methylbenzamide | HCID 20806794 | — |
Reaction Steps
The title compound was prepared according to the procedure for Compound 102A (2-Amino-5-fluoro-N-methylbenzamide) using 2-fluoro-N-methyl-6-nitrobenzamide (Compound 155B). 1H NMR (CDCl3, 400 MHz): δ=2.99 (dd, J=4.80, 1.26 Hz, 3H), 6.35 (ddd, J=12.88, 8.08, 1.01 Hz, 1H), 6.44-6.49 (m, 1H), 7.09 (td, J=8.21, 6.57 Hz, 1H). MS (ES+): m/z 169.08 [MH+] (TOF, polar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399433B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-c7b89e9cbe2e43e4b28a4d55cff25026 |
| Source note | uspto-grants-2013_03 |