Diethyl [4-({4-[(7-cyano-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate → Diethyl[4-({4-[(7-cyano-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)-3-methoxybenzyl]phosphonate
반응식
[CH2:1]([O:3][P:4]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]2[N:22]=[C:21]([NH:23][C:24]3[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[C:29]4[C:25]=3[C:26](=[O:36])[N:27]([CH3:35])[CH2:28]4)[C:20]([C:37]([F:40])([F:39])[F:38])=[CH:19][N:18]=2)=[CH:12][CH:11]=1)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].BrC1C=CC(NC2C(C(F)(F)F)=CN=C(NC3C=CC(CP(=O)([O-])[O-])=CC=3OC)N=2)=C2C=1CN(C)[C:47]2=[O:52]>>[CH2:6]([O:5][P:4]([CH2:9][C:10]1[CH:11]=[CH:12][C:13]([NH:16][C:17]2[N:22]=[C:21]([NH:23][C:24]3[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[C:29]4[C:25]=3[C:26](=[O:36])[N:27]([CH3:35])[CH2:28]4)[C:20]([C:37]([F:39])([F:38])[F:40])=[CH:19][N:18]=2)=[C:14]([O:52][CH3:47])[CH:15]=1)(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was prepared according to the procedure for Diethyl[4-({4-[(7-cyano-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate (Example 161) using [4-({4-[(7-bromo-2-methyl-3-oxo-2,3-dihydro-1 H-isoindol-4-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)-3-methoxybenzyl]phosphonate. MS (ES+): m/z 605.19 (100) [MH+] HPLC: tR=1.09 min (UPLC, purity).
출처 및 근거
- ORD 기록
- ord-c1c3de1a5424473580f74afb95edc454
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08399433B2
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