Diethyl (4-{[4-chloro-5-(trifluoromethyl) pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → HCID 178476873, compound

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The title compound was prepared according to the procedure for Example 102 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 7-amino-4-(cis-4-ethoxycyclohexyl)-2-methyl-2,3-dihydro-1H-isoindol-1-one (Compound 166A). 1H NMR (DMSO-d6, 400 MHz): δ=1.15-1.22 (m, 9H), 1.44-1.56 (m, 4H), 1.69-1.82 (m, 2H), 1.95 (d, J=11.62 Hz, 2H), 2.53-2.63 (m, 1H), 3.07 (s, 3H), 3.22-3.30 (m, 2H), 3.45 (q, J=6.99 Hz, 2H), 3.60 (br. s., 1H), 3.75 (s, 3H), 3.94-4.04 (m, 4H), 4.49 (s, 2H), 6.91 (d, J=7.58 Hz, 1H), 7.06 (s, 1H), 7.18 (br. s., 1H), 7.49 (br. s., 1H), 8.22-8.48 (m, 2H), 9.00 (br. s., 1H), 10.56 (s, 1H). MS (ES+): m/z 706.30 [MH+] (TOF, polar).

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