HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxy-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one → 7-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxy-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one | HCID 59849179 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 7-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one | HCID 67253941 | — |
Reaction Steps
Pd/C (7.67 mg, 0.0720 mmol) was added to a solution of 4-methoxy-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one in MeOH (2 mL) and EtOAc (2 mL) and the mixture was hydrogenated at stp overnight. The solution was filtered and the title compound was not further purified. MS (ES+): m/z 193.14 (100) [MH+]; HPLC: tR=0.65 min (UPLC, analytical).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399433B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-a87f3dea0bc242039965186afe1938a9 |
| Source note | uspto-grants-2013_03 |