HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1948019Generated: October 30, 2026
Morpholine → 2-Methyl-4-(morpholin-4-yl)-7-nitro-2,3-dihydro-1H-isoindol-1-one
https://huagongshe.com/reaction/1948019
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Bromo-2-methyl-7-nitroisoindolin-1-one | HCID 53407894 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Methyl-4-(morpholin-4-yl)-7-nitro-2,3-dihydro-1H-isoindol-1-one | HCID 67254062 | — |
Reaction Steps
A mixture of 4-Bromo-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one (100.0 mg, 0.3689 mmol), morpholine (321.7 uL, 3.689 mmol), DIPEA (642.6 uL, 3.689 mmol) in DMF (4 mL) were mixed in sealed tube under an atmosphere of argon and heated at 90° C. for 4 days. The crude material was purified by MDP directly under basic conditions the desired product. MS (ES+): m/z 278.24 (100) [MH+]; HPLC: tR=0.81 min (UPLC, analytical).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08399433B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-8f6ebd7bffae4dcc98734c3c217dbc80 |
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| Source note | uspto-grants-2013_03 |
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