2,4-Dichloro-5-(trifluoromethyl)pyrimidine → 2-chloro-N-{4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]phenyl}-5-(trifluoromethyl)pyrimidin-4-amine

HRID 1948037Notes

Reaction equation

HRID 1948037 reaction equation
[CH2:1]([O:3][P:4]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]2[N:22]=[C:21]([Cl:23])C(C(F)(F)F)=CN=2)=[CH:12][CH:11]=1)(=[O:8])[O:5][CH2:6][CH3:7])C.O=P1(CC2C=CC(N)=CC=2)OCCCO1.ClC1N=C(Cl)[C:47]([C:51]([F:54])([F:53])[F:52])=[CH:46][N:45]=1>>[Cl:23][C:21]1[N:22]=[C:17]([NH:16][C:13]2[CH:12]=[CH:11][C:10]([CH2:9][P:4]3(=[O:8])[O:3][CH2:1][CH2:7][CH2:6][O:5]3)=[CH:15][CH:14]=2)[C:47]([C:51]([F:54])([F:53])[F:52])=[CH:46][N:45]=1

Participants

4

Reactant 3

HCID 27827742,4-Dichloro-5-(trifluoromethyl)pyrimidineHCID 112991132-(4-Aminobenzyl)-1,3,2-dioxaphosphorinane-2-oxide2×HCID 86654003Diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Product 1

HCID 582929812-chloro-N-{4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]phenyl}-5-(trifluoromethyl)pyrimidin-4-amine

Procedure

The title compound was prepared according to the procedure for diethyl(4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate using 4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]aniline (Compound 230C) and 2,4-dichloro-5-trifluoromethylpyrimidine.

Sources & evidence

ORD record
ord-436bbcb8f96048ef861f96f6fff11712
Source dataset
uspto-grants-2013_03
Patent number
US08399433B2

Reaction notes

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