反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
This compound was prepared according to the procedure for Example 102 using diethyl(4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 7-amino-4-{4-[ethyl(methyl)amino]cyclohexyl}-2-methyl-2,3-dihydro-1H-isoindol-1-one (Compound 236A). 1H NMR (400 MHz, MeOD) δ ppm 1.28 (t, J=7.07 Hz, 6H) 1.39 (t, J=7.33 Hz, 3H) 1.70-1.86 (m, 4H) 2.04 (br. s., 2H) 2.19 (d, J=7.83 Hz, 2H), 2.71 (br. s., 1H) 2.86 (s, 3H) 3.17-3.19 (m, 3H) 3.33 (s, 1H) 3.34-3.37 (m, 2H) 3.39 (s, 1H) 3.43-3.52 (m, 1H) 3.89 (s, 3H) 4.05-4.14 (m, 4H) 4.55 (s, 2H) 7.01 (dt, J=8.02, 2.31 Hz, 1H), 7.15 (t, J=2.02 Hz, 1H) 7.42 (d, J=8.34 Hz, 1H) 7.57 (d, J=8.08 Hz, 1H) 8.36 (br. s., 1H). MS (ES+): m/z 719.25/720.29 (100/20) [MH+]. HPLC: tR=1.17 min (UPLC TOF: polar—3 min).
WORKUP
后处理
- customThis compound was prepared
- customHPLC: tR=1.17 min (UPLC TOF: polar—3 min)