Trifluoroacetic acid → HCID 58292933, compound

Participants

Reaction Steps

To tert-butyl 4-(7-{[2-({4-[(diethoxyphosphoryl)methyl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-4-yl]amino}-2-methyl-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-3,6-dihydropyridine-1(2H)-carboxylate (Compound 246A, 180 mg, 0.25 mmol) was added methylene chloride (1 mL) and trifluoroacetic acid (1 mL). The mixture was stirred at room temperature for 1 hour, after which, the reaction mixture was concentrated and purified by MDP. 1H NMR (400 MHz, methanol-d4) δ=1.27 (t, J=6.9 Hz, 6H), 2.77-2.85 (m, 2H), 3.19 (s, 3H), 3.29 (d, J=21.5 Hz, 2H), 3.50 (t, J=6.1 Hz, 2H), 3.88-3.94 (m, 2H), 4.01-4.17 (m, 4H), 4.59 (s, 2H), 6.02 (dt, J=3.3, 1.7 Hz, 1H), 7.35 (dd, J=8.5, 2.4 Hz, 2H), 7.50 (d, J=8.8 Hz, 1H), 7.57 (d, J=8.1 Hz, 2H), 8.35-8.43 (m, 1H), 8.72 (br. s., 1H). MS (ES+): m/z 631.23 (100) [MH+]; HPLC: tR=0.68 min (UPLC, purity).

Provenance & Evidence