2-Amino-5-fluoro-N-methylbenzamide → HCID 58292879, compound

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The title compound was prepared according to Compound 102A using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (45.4 mg, 0.100 mmol) and diethyl[(5-amino-3-methyl-4-oxoquinolin-1(4H)-yl)methyl]phosphonate hydrochloride (Compound 303A, 39.7 mg, 0.110 mmol). 1H NMR (CD3OD, 400 MHz): δ=1.24 (t, J=7.2 Hz, 6H), 1.28 (t, J=7.2 Hz, 6H), 2.12 (s, 3H), 3.28 (d, J=21.2 Hz, 2H), 3.91 (s, 3H), 4.06-4.11 (m, 8H), 4.86 (s, 2H), 6.91 (d, J=8.4 Hz, 1H), 7.04 (m, 1H), 7.44 (d, J=8.8 Hz, 1H), 7.62 (m, 1H), 7.92 (s, 1H), 7.96 (dd, J=2.4, 8.4 Hz, 1H), 8.37 (s, 1H), 8.67 (d, J=8.0 Hz, 1H). MS (ES+): m/z 742.18 [MH+]. HPLC: tR=1.44 min (UPLC TOF, polar—3 min).

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