反应详情

温度

-78 °C

13.4 ml (26.8 mmol) of a 2M solution of ethylmagnesium chloride in diethyl ether were diluted using 8 ml of anhydrous diethyl ether and cooled to −78° C. At that temperature, a solution of 3.7 g (8.95 mmol) of 2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-trifluoromethyl-cyclohexyl]methylideneamide (72) in anhydrous diethyl ether was added dropwise. Afterwards, the mixture was allowed to warm to ambient temperature and was stirred for 2 h at ambient temperature. 100 ml of a saturated aqueous Na2SO4-solution was added, the organic layer separated, dried using MgSO4 and evaporated to give 3.22 g of 73 as an oil, used without further purification. Rt=1.09 min (Method Q).

1. temperatureto warm to ambient temperature
2. customthe organic layer separated
3. customdried
4. customevaporated