Sodium Bicarbonate → HCID 70236756, compound

Participants

Reaction Steps

5.50 g of [1-(8-methyl-1,4-dioxa-spiro[4.5]dec-8-yl)-propyl]-carbamic acid benzyl ester (77) were dissolved in 15 mL of a 2:1 mixture of acetone and 6N aqueous hydrochloric acid. The reaction mixture was stirred for 16 h at room temperature, then dropped into 150 mL of saturated aqueous sodium bicarbonate solution. The mixture was extracted three times with dichloromethane (100 mL each), the combined organic phases were dried over magnesium sulphate, filtered and concentrated to give the ketone 78, which was used directly in the next step. Rt=0.59 min (Method P). Detected mass: 304.2 (M+H+).

Provenance & Evidence