Ammonium Acetate → HCID 67072976, compound

Participants

Reaction Steps

2.10 g (6.92 mmol) of the ketone (78) were dissolved in 21 mL of absolute methanol, then 5.34 g (69.2 mmol) of ammonium acetate and 435 mg (6.92 mmol) of sodium cyanoborohydride were added, and the mixture was stirred at room temperature for 16 h. The reaction mixture was evaporated, the residue dissolved in 50 mL of 1N aqueous sodium hydroxide and extracted twice with 100 mL of dichloromethane. The combined organic layer was dried over magnesium sulphate, filtered, and evaporated to give 1.70 g of the title compound 79 in a purity sufficient to be used directly in the next step. Rt=0.75 min (Method P). Detected mass: 305.2 (M+H+).

Provenance & Evidence