HCID 67072585, compound → HCID 44599823, compound

Participants

Reaction Steps

66 mg (153 μmol) of {1-[4-(Isoquinolin-6-ylamino)-1-methyl-cyclohexyl]-propyl}-carbamic acid benzyl ester (80) were dissolved in 500 μL of dry methanol and 5 mg of palladium on activated charcoal (10%) were added. The mixture was stirred under a hydrogen atmosphere until conversion was complete. The catalyst was filtered off and the reaction mixture was evaporated to dryness to give the title compound, which was purified by reversed phase HPLC (water/acetonitrile) to give 30 mg of pure Example 111 as its trifluoroacetic acid salt. Rt=1.02 min (Method L). Detected mass: 298.2 (M+H+).

Provenance & Evidence