HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorobenzyl bromide → 5-Bromo-1-(3-fluorobenzyl)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorobenzyl bromide | HCID 68007 | — |
| Reactant | 5-Bromo-2-hydroxypyridine | HCID 599528 | — |
| Product | 5-Bromo-1-(3-fluorobenzyl)pyridin-2(1H)-one | HCID 60627653 | 62% |
Reaction Steps
According to Scheme 1 Step 2: 1-(3-Fluorobenzyl)-5-bromopyridin-2(1H)-one was prepared from 5-bromopyridin-2(1H)-one (Example 1 Step 1) and 3-fluorobenzyl bromide according to the procedure described for Example 2 Step 1. The crude product washed with pentane/Et2O 50/50 to afford 1-(3-fluorobenzyl)-5-bromopyridin-2(1H)-one (10.7 mmol, 3.00 g, 62%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399493B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-0392181931214d6895b9cc6ab62bf4a2 |
| Source note | uspto-grants-2013_03 |