2-Bromo-1,3-benzothiazole → 2-(6-Methoxypyridin-3-yl)benzo[d]thiazole

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Reaction Steps

According to Scheme 4 Method A: The title compound was prepared from 2-bromobenzo[d]thiazole (1 eq, 0.91 mmol, 0.20 g) and 6-methoxypyridin-3-ylboronic acid (1.5 eq, 1.36 mmol, 0.21 g) according to the procedure described for Example 2 Step 2. The crude product was purified by silica gel chromatography (AIT Flashsmart prepacked column 25 g SiO2) using cyclohexane/AcOEt 95/5 as eluent to afford 2-(6-methoxypyridin-3-yl)benzo[d]thiazole (0.74 mmol, 0.18 g, 82%) as a white solid.

Provenance & Evidence