HCID 22049898, compound → HCID 54724162, compound

HRID 1948214Notes

Reaction equation

HRID 1948214 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][CH:24]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([O:12]CC2C=CC=C(F)C=2)=[CH:8][C:7]1=[O:21]>CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][CH:24]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]1=[O:21]

Participants

4

Reactant 1

HCID 22049898HCID 22049898, compound

Product 1

HCID 54724162HCID 54724162, compoundYield 79%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

According to Scheme 13 Step 2: A suspension of 1-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)pyridin-2(1H)-one (1 eq, 0.95 mmol, 0.29 g) and Pd/C (0.3 eq, 0.29 mmol, 30.3 mg) in MeOH (3 mL) was hydrogenated until complete (30 min). The suspension was filtered through celite and the filtrate concentrated under vacuum to afford 1-(3-fluorobenzyl)-4-hydroxypyridin-2(1H)-one (0.75 mmol, 0.16 g, 79%) as a white powder.

Workup

  1. customwas hydrogenated until complete (30 min)
  2. filtrationThe suspension was filtered through celite
  3. concentrationthe filtrate concentrated under vacuum

Sources & evidence

ORD record
ord-55f99ad0acf54c64bafd97d35faecc28
Source dataset
uspto-grants-2013_03
Patent number
US08399493B2

Reaction notes

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