4-(Bromomethyl)-1,2-difluorobenzene → HCID 58966905, compound

Participants

Reaction Steps

According to Scheme 16 Method A: The title compound was prepared from 2-methoxy-5-(phenoxymethyl)pyridine (1 eq, 0.46 mmol, 0.10 g) and 4-(bromomethyl)-1,2-difluorobenzene (3 eq, 1.39 mmol, 0.18 mL) according to the procedure described for Example 1 Step 2. Reaction conditions: under reflux for 3 days in DMF (5 mL). The crude oil was purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 25 g SiO2) using CH2Cl2/AcOEt 90/10 followed by recrystallization in diisopropyl ether to afford 1-(3,4-difluorobenzyl)-5-(phenoxymethyl)pyridin-2(1H)-one (0.14 mmol, 0.04 g, 29%) as a white solid.

Provenance & Evidence