2-(4-Iodo-imidazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine → N-tert-Butyl-5-{1-[4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonamide

HRID 194824Notes

Reaction equation

HRID 194824 reaction equation
[C:24]([CH3:25])([CH3:26])([CH3:27])[NH:28][S:29](=[O:30])(=[O:31])[c:32]1[s:33][c:34]([B:37]2[O:38][C:39]([CH3:40])([CH3:41])[C:42]([CH3:43])([CH3:44])[O:45]2)[cH:35][cH:36]1.[I:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH3:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[n:12]2)[cH:6]1>>[c:2]1(-[c:34]2[s:33][c:32]([S:29]([NH:28][C:24]([CH3:25])([CH3:26])[CH3:27])(=[O:30])=[O:31])[cH:36][cH:35]2)[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH3:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[n:12]2)[cH:6]1

Participants

3

Reactant 2

HCID 574687852-(4-Iodo-imidazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidineHCID 57468817N-tert-butyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-sulfonamide

Product 1

HCID 57468941N-tert-Butyl-5-{1-[4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonamide

Sources & evidence

ORD record
ord-e835472952d14990867a4b3871b22574
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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