4-(Bromomethyl)benzyl alcohol → HCID 69349835, compound

HRID 1948243Notes

Reaction equation

HRID 1948243 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)=[CH:5][N:4]=1.Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][OH:26])=[CH:21][CH:20]=1>>[OH:26][CH2:25][C:22]1[CH:23]=[CH:24][C:19]([CH2:18][N:4]2[CH:5]=[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=3)[CH:7]=[CH:8][C:3]2=[O:2])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 103304344-(Bromomethyl)benzyl alcoholHCID 54762487HCID 54762487, compound

Product 1

HCID 69349835HCID 69349835, compoundYield 80.4%

Procedure

According to Scheme 4 Step 1: The title compound was prepared according to Example 6 Step 2, from 2-methoxy-5-(4-methoxyphenyl)pyridine (1 eq, 4.60 mmol, 1.00 g) and (4-(bromomethyl)phenyl)methanol (1.1 eq, 5.10 mmol 1.00 g). Reaction conditions: 5 hours at 70° C. and room temperature overnight. The residue was triturated with pentane, yielding the title compound (3.70 mmol, 1.20 g, 80%).

Workup

  1. customThe title compound was prepared
  2. customReaction conditions
  3. custom5 hours
  4. customat 70° C.
  5. customroom temperature overnight
  6. customThe residue was triturated with pentane

Sources & evidence

ORD record
ord-a14ab8f6bb324186888b5f98e2da9ca3
Source dataset
uspto-grants-2013_03
Patent number
US08399493B2

Reaction notes

Loading…