Iodoethane → HCID 58966957, compound

Participants

Reaction Steps

According to Scheme 25 Method A: The title compound was prepared from 1-(4-chlorobenzyl)-5-(4-(hydroxymethyl)phenyl)pyridin-2(1H)-one (1 eq, 2.50 mmol, 0.80 g) and iodoethane (3 eq, 7.40 mmol, 1.10 g)) according to the procedure described for Example 34 Step 3. The crude product was purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 5 g SiO2) using CH2Cl2/MeOH 99/1 as eluent to afford 1-(4-chlorobenzyl)-5-(4-(ethoxymethyl)phenyl)pyridin-2(1H)-one (1.02 mmol, 0.36 g, 41%) as a yellow solid.

Provenance & Evidence