4-Bromoisoquinoline → HCID 11391278, compound

Participants

Reaction Steps

According to Scheme 29 Step 1: The title compound was prepared from 4-bromoisoquinoline (1 eq, 5.30 mmol, 1.10 g) and 1-ethynyl-4-methoxybenzene (1 eq, 5.30 mmol, 0.70 g) according to the procedure described for Example 13 Step 1. Reaction conditions: 70° C. for 4 hours. The crude product was purified by silica gel chromatography (AIT Flashsmart prepacked column SiO2, cyclohexane/AcOEt 90/10 to 80/20) to afford 4-(2-(4-methoxyphenyl)ethynyl)isoquinoline (3.11 mmol, 0.81 g, 59%) as a white solid.

Provenance & Evidence