Trifluoroacetic acid → HCID 58966936, compound

Participants

Reaction Steps

According to Scheme 19 Step 5: tert-Butyl 4-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)phenyl(2-(dimethylamino)ethyl)carbamate (0.16 mmol, 79.0 mg) was dissolved in dry CH2Cl2 (30 mL). Then TFA (7 mL) was added dropwise and the resulting solution was stirred at room temperature for 3 hours. Then the solvent was evaporated under reduced pressure and the resulting residue thus obtained was resulting suspension was taken up in CH2Cl2, washed with a saturated aqueous NaHCO3 solution. The organic solvent was separated, dried (Na2SO4) and the solvent was evaporated under reduced pressure. The residue was purified in a manifold (vac.) using a Sep-Pak silica cartridge CH2Cl2/MeOH(NH3)sat. 95/5. The product fractions were collected and the solvent was evaporated to yield 1-(4-chlorobenzyl)-5-(4-(2-(dimethylamino)ethylamino)phenyl)pyridin-2(1H)-one (16.4 mg, 26%)

Provenance & Evidence