Sodium Iodide → 1-(4-chlorobenzyl)-5-(4-methoxybenzyloxy)pyridine-2(1H)-one

참여 물질

반응 단계

According to Scheme 32 Step 1: 2-Methoxy-5-(4-methoxybenzyloxy)pyridine (1.38 mmol, 339 mg), 4-chlorobenzylchloride (2.76 mmol, 468 mg), NaI (1.38 mmol, 207 mg) in acetonitrile (15 mL) was heated at 150° C. for 50 minutes under microwave conditions. The cooled crude reaction washed with water, extracted with AcOEt. The organic layer was collected, dried (Na2SO4) and the solvent was evaporated under reduced pressure. The residue was purified in a manifold (vac.) using a Sep-Pak silica cartridge CH2Cl2 and CH2Cl2/acetone 90/10) yielding 1-(4-chlorobenzyl)-5-(4-methoxybenzyloxy)pyridine-2(1H)-one (141 mg, 29%).

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