Morpholine → HCID 131730310, compound

HRID 1948292Notes

Reaction equation

[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[S:19][C:20]([C:23]([O:25][CH3:26])=[O:24])=[CH:21][N:22]=2)[CH2:14][C@H:13]1[C:27]([OH:29])=O)=[O:10].[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[S:19][C:20]([C:23]([O:25][CH3:26])=[O:24])=[CH:21][N:22]=2)[CH2:14][C@H:13]1[C:27]([N:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1)=[O:29])=[O:10]

Participants

Reactant 2

HCID 8083Morpholine

HCID 86643335HCID 86643335, compound

Product 1

HCID 131730310HCID 131730310, compound

Procedure

The title compound was prepared in a manner analogous to (Intermediate 37) starting from cis(±)4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-1-[5-(methoxycarbonyl)-1,3-thiazol-2-yl]piperidine-3-carboxylic acid (Example 77) and morpholine. MS (ES+): 530, 532 for C21H25Cl2N5O5S.

Sources & evidence

ORD record: ord-c2aa866f066246489a7fcfaa82eb6543
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399489B2

Reaction notes

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