Ethyl 4-bromo-5-methyl-1H-pyrrole-2-carboxylate → 4-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid

HRID 1948349Notes

Reaction equation

HRID 1948349 reaction equation
ClC1C(Cl)=C(C)NC=1C(N[C@@H]1CCN(C2SC(C([O-])=O)=CN=2)C[C@@H]1F)=O.OCC(CO)([NH3+])CO.[Br:35][C:36]1[CH:37]=[C:38]([C:42]([O:44]CC)=[O:43])[NH:39][C:40]=1[CH3:41]>>[Br:35][C:36]1[CH:37]=[C:38]([C:42]([OH:44])=[O:43])[NH:39][C:40]=1[CH3:41]

Participants

3

Reactant 2

HCID 58066105Ethyl 4-bromo-5-methyl-1H-pyrrole-2-carboxylateHCID 685177971,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium 2-((3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-fluoropiperidin-1-yl)-1,3-thiazole-5-carboxylate

Product 1

HCID 685182224-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid

Procedure

Prepared by the procedure described for Intermediate 1 using Intermediate 187 as the starting material.

Workup

  1. customPrepared by the procedure

Sources & evidence

ORD record
ord-6d34cc1adc5b4e268c201b9110f83af2
Source dataset
uspto-grants-2013_03
Patent number
US08399489B2

Reaction notes

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