HCID 86623151, compound → HCID 11998794, compound

Participants

Reaction Conditions

Reaction Steps

N-{5-[2-Bromo-5-(4-methoxy-piperidine-1-sulfonyl)-thiophen-3yl]-4-methyl-thiazol-2-yl}-acetamide obtained in Step I as described above (250 mg; 0.51 mmol; 1 eq), is dissolved in anhydrous THF (20 ml). The reaction mixture is cooled down to −70° C. and put under nitrogen. n-Butyllithium (2 ml; 1.6 M; 4.04 mmol; 8 eq) is added dropwise. The reaction is stirred 40 minutes and quenched with water. Solvents are evaporated and the resulting crude product is purified by preparative HPLC, affording Compound (34) as a white-off powder (127 mg; 47%).

Provenance & Evidence