4-(Bromoacetyl)benzonitrile → HCID 86656387, compound

Participants

Reaction Steps

To a solution of commercially available (S)-ethyl piperidine-3-carboxylate (10 g, 63.6 mmol) in 200 mL toluene was added 4-(2-bromoacetyl)benzonitrile (17 g, 76 mmol). The reaction mixture was stirred overnight. The next day, the precipitated solid was collected by filtration and washed with ethyl acetate (×3) and dried under vacuum to give 15.2 g of (S)-ethyl 1-(2-(4-cyanophenyl)-2-oxoethyl)piperidine-3-carboxylate hydrobromide. MS (M+1)=301. HPLC Peak RT=1.51 minutes.

Provenance & Evidence