4-(Bromoacetyl)benzonitrile → HCID 58374171, compound

Participants

Reaction Steps

To a mixture of (S)-ethyl piperidine-3-carboxylate (5 g, 31.8 mmol) in toluene (50 mL) was added 4-(2-bromoacetyl)benzonitrile (7.84 g, 35.0 mmol). The reaction mixture was stirred for 48 hours. The reaction mixture was concentrated in vacuo to yield 12 g of a yellow solid which was purified by triturating in EtOAc. The solid material was collected and washed with EtOAc then dried in vacuo to give 6 g of (S)-ethyl 1-(2-(4-cyanophenyl)-2-oxoethyl)piperidine-3-carboxylate, hydrobromide. MS (m+1)=301. HPLC Peak RT=1.57 minutes (Analytical Method B).

Provenance & Evidence