反应详情

To a mixture of tert-butyl 1-(2-(4-cyanophenyl)-2-oxoethyl)azetidine-3-carboxylate, hydrobromide (170 mg, 0.446 mmol) in MeOH (5 mL) was added sodium borohydride (25 mg, 0.661 mmol). The reaction mixture was stirred for 1 hour. The reaction was quenched with water. The reaction mixture was diluted with ethyl acetate and washed with H2O. The organic layer was dried with MgSO4, filtered, and concentrated to yield 100 mg of tert-butyl 1-(2-(4-cyanophenyl)-2-hydroxyethyl)azetidine-3-carboxylate. MS (m+1)=303. HPLC Peak RT=0.90 minutes (Analytical Method B).

1. customThe reaction was quenched with water
2. additionThe reaction mixture was diluted with ethyl acetate
3. washwashed with H2O
4. dry with materialThe organic layer was dried with MgSO4
5. filtrationfiltered
6. concentrationconcentrated