m-Chloroperbenzoic acid → HCID 86656397, compound

Participants

Reaction Steps

To a mixture of 5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole (56 mg, 0.124 mmol) in DCM (5 mL) was added mCPBA (64.2 mg, 0.372 mmol). The reaction mixture was stirred overnight. The reaction mixture was diluted with dichloromethane and washed with 1N NaOH. The organic layer was dried with MgSO4, filtered, and concentrated to yield 50 mg of 3-(4-(oxiran-2-yl)-2-(trifluoromethyl)phenyl)-5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole. MS (m+1)=468. HPLC Peak RT=2.12 minutes (Analytical Method B).

Provenance & Evidence