Sodium Hydroxide → HCID 58374090, compound

Participants

Reaction Steps

To a solution of ethyl 1-(4-chlorophenyl)-5-(trifluoromethyl)-1H-imidazole-4-carboxylate (800 mg, 2.51 mmol) in EtOH (20 mL) was added a predissolved solution of sodium hydroxide (1004 mg, 25.1 mmol) in Water (5.00 mL). The reaction was stirred overnight at room temperature. The next day, the reaction was concentrated in vacuo, acidified with dilute HCl and extracted 2×EtOAc. The organic layers were dried over MgSO4, filtered, and concentrated to give 1-(4-chlorophenyl)-5-(trifluoromethyl)-1H-imidazole-4-carboxylic acid (400 mg, 1.376 mmol, 54.8% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 13.3 (1H, br s), 8.19 (1H, dd), 7.68 (2H, d), 7.72 (2H, d).

Provenance & Evidence