Hydrochloric Acid → HCID 58408400, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of methyl 2-(1-methyl-1H-pyrazol-4-yl)-5-(5-methylpyridin-3-yl)benzoate (2-4, 0.216 g, 0.703 mmol, 1.0 equiv) in isopropanol/water (3:1, 4 mL) was added 1M lithium hydroxide solution (0.773 mL, 0.773 mmol, 1.1 equiv) and the reaction was heated to 80° C. for 15 minutes in the microwave. The reaction mixture was cooled and the pH was adjusted to ˜7 by the addition of 1N HCl. The reaction mixture was concentrated and the solids azeotroped from toluene to afford the product as a solid. ESI+ MS [M+H]+ C12H15N3O2: 308.02 found, 308.36 required.

Provenance & Evidence