Water → Methyl-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)amine

Participants

Reaction Steps

LiAlH4 (535 mg, 14.08 mmole) was suspended in dry THF (4 ml) with the exclusion of atmospheric moisture. 8-isocyanato-8-phenyl-1,4-dioxaspiro[4.5]decane (2.29 g, 8.8 mmole, dissolved in 40 ml of dry THF) was then added dropwise within 20 minutes. After the end of the addition the reaction mixture was boiled under reflux for 4 hours. After cooling the reaction mixture, aqueous THF (1 ml H2O in 3 ml) was first of all carefully added, followed by 1.7 ml of 15% sodium hydroxide solution and finally 5 ml of H2O. The reaction mixture was stirred for 20 minutes and then filtered through diatomaceous earth. The solvent mixture obtained by washing the filter cake several times with ethyl acetate was concentrated by evaporation to dryness on a rotary evaporator. The desired product was obtained in a yield of 2.1 g (97%) as a viscous oil.

Provenance & Evidence