HCID 68977387, compound → HCID 68841554, compound

Participants

Reaction Steps

6N hydrochloric acid (10 ml) was added to (8-benzo[1,3]dioxol-5-yl-1,4-dioxa-spiro[4.5]dec-8-yl)-dimethylamine hydrochloride (2.70 g, 7.91 mmole) and stirred overnight at RT. After completion of the hydrolysis the reaction mixture was extracted with ether (2×20 ml), the aqueous solution was made alkaline with 5N sodium hydroxide solution while cooling with ice, the reaction mixture was extracted with dichloromethane (3×50 ml), and the organic phase was dried over sodium sulfate and concentrated by evaporation in vacuo.

Provenance & Evidence