Hydrochloric Acid → HCID 57475101, compound

Participants

Reaction Steps

The 8-benzo[b]thiophen-2-yl-1,4-dioxa-spiro[4.5]dec-8-yl)-dimethylamine hydrochloride (0.60 g, 1.7 mmole) was dissolved in water (0.8 ml), conc. hydrochloric acid (1.04 ml, 151 mmole) was added, and the mixture was stirred for 3 days at room temperature. After completion of the hydrolysis the reaction mixture was extracted with diethyl ether (2×25 ml) and the aqueous phase was made alkaline with 5N sodium hydroxide solution, extracted with dichloromethane (3×25 ml), dried over sodium sulfate and concentrated by evaporation in vacuo.

Provenance & Evidence