Hydrochloric Acid → HCID 68843024, compound

Participants

Reaction Steps

5% hydrochloric acid (330 ml) was added at room temperature to methyl-[8-(2-methyl-2H-[1,2,4]triazol-3-yl)-1,4-dioxaspiro[4.5]dec-8-yl]-amine (4.2 g, 16.646 mmole) and the mixture was stirred for 3 days at room temperature. Ether (120 ml) was added to the reaction mixture. The phases were separated. The aqueous phase was made alkaline with 5N NaOH and extracted with dichloromethane (4×50 ml). The organic phase was dried over sodium sulfate and concentrated by evaporation to dryness in vacuo. The product was obtained as a colourless crystalline solid in a yield of 83% (2.89 g, 13.862 mmole).

Provenance & Evidence