HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → HCID 15351005, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 68841605 | HCID 68841605 | — |
| Product | HCID 15351005 | HCID 15351005 | 94.8% |
Reaction Steps
2-(2-(triethylsilyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanol (3.8 g, 11.0 mmole) was stirred with TBAF (33.1 ml, 33.1 mmole; 1M solution in THF) for 6 hours at 50° C. and then for 10 hours at RT. The solvent was removed on a rotary evaporator. 2-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanol (2.4 g, 94.5%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399503B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-5b9fa11f262f4af482351657936275b5 |
| Source note | uspto-grants-2013_03 |