5-(2-Pyridyl)thiophene-2-sulfonyl chloride → HCID 66886467, compound

HRID 1948648Notes

Reaction equation

HRID 1948648 reaction equation
N1C=CC(/C=C/C(O)=O)=C1.[C:11]([O:15][C:16](=[O:24])/[CH:17]=[CH:18]/[C:19]1[CH:23]=[CH:22][NH:21][CH:20]=1)([CH3:14])([CH3:13])[CH3:12].[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31]1[S:35][C:34]([S:36](Cl)(=[O:38])=[O:37])=[CH:33][CH:32]=1>>[C:11]([O:15][C:16](=[O:24])/[CH:17]=[CH:18]/[C:19]1[CH:23]=[CH:22][N:21]([S:36]([C:34]2[S:35][C:31]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][N:25]=3)=[CH:32][CH:33]=2)(=[O:37])=[O:38])[CH:20]=1)([CH3:14])([CH3:12])[CH3:13]

Participants

4

Reactant 3

HCID 27372315-(2-Pyridyl)thiophene-2-sulfonyl chlorideHCID 537232585310-57-2HCID 66646340tert-butyl (2E)-3-(1H-pyrrol-3-yl)prop-2-enoate2×

Product 1

HCID 66886467HCID 66886467, compound

Procedure

Starting from (E)-3-(1H-pyrrol-3-yl)-acrylic acid tent-butyl ester (compound D1) and art-known 5-pyridin-2-yl-thiophene-2-sulfonylchloride the title compound can be obtained analogously or similarly as described for compound C1.

Sources & evidence

ORD record
ord-b883198ffb11402c96e53ee2f1bd3c87
Source dataset
uspto-grants-2013_03
Patent number
US08399505B2

Reaction notes

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