p-Toluenesulfonic acid → HCID 59450529, compound

Participants

Reaction Conditions

Reaction Steps

TsOH (850 mg, 9.449 mmol) was added to a stirred mixture of 1-hydroxy-2,3-dihydro-1H-inden-5-yl benzoate (120 g, 472.441 mmol) and MgSO4 (113.4 g, 944.882 mmol) in toluene at rt under nitrogen, and the reaction mixture was stirred at 90-100° C. overnight. The solid was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (PE) to give the title compound. 1H-NMR (400 MHz, CDCl3): δ 8.22-8.24 (m, 2H), 7.62-7.66 (m, 1H), 7.50-7.54 (m, 2H), 7.42 (d, J=8.1 Hz, 1H), 7.34 (d, J=1.2 Hz, 1H), 7.12 (dd, J=8.1 Hz, J=2.0 Hz, 1H), 6.88-6.90 (m, 1H), 6.57-6.59 (m, 1H), 3.44 (s, 2H) ppm.

Provenance & Evidence