HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1948671Generated: October 31, 2026
Thionyl Chloride → 2-(Chloromethyl)-1-fluoro-4-iodo-3-methylbenzene
https://huagongshe.com/reaction/1948671
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (6-Fluoro-3-iodo-2-methylphenyl)methanol | HCID 59450541 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-(Chloromethyl)-1-fluoro-4-iodo-3-methylbenzene | HCID 59450551 | — |
Reaction Steps
To a solution of the product of Step C (4.01 g, 15.4 mmol) in anhydrous benzene (40 mL) was added dropwise thionyl chloride (3.7 g, 30.8 mmol). The mixture was stirred 80° C. overnight. The mixture was cooled to rt, washed with saturated aqueous sodium bicarbonate solution, water and brine, and dried over magnesium sulfate, and concentrated to dryness to give the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08399507B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-4bf1d041511248fdbbe0683681c020c1 |
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| Source note | uspto-grants-2013_03 |
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