Cesium fluoride → HCID 59450554, compound

Participants

Reaction Conditions

Reaction Steps

To a two-neck round bottom flask with a magnetic stirring bar, was added tris(dibenzylideneacetone)dipalladium(0) (29.5 mg, 0.032 mmol), tri-t-butylphosphonium tetrafluoroborate (18.6 mg, 0.064 mmol), cesium fluoride (652 g, 4.29 mmol), 2,6-dichlorophenylboronic acid (409 mg, 2.15 mmol), and the product of Step E (500 mg, 1.07 mmol). One neck of the flask was connected to a vacuum line while another neck was fitted with an argon balloon. The flask was then purged 8-10 times with argon. The vacuum line was replaced with a septum and anhydrous THF (10 mL) was added by syringe. The mixture was stirred in a 70° C. oil bath for 16 h. The reaction solution was filtrated and concentrated. The residue was carried on to hydrolysis at the next step without purification.

Provenance & Evidence