3,4-Diaminobenzonitrile → 2-Hydroxyquinoxaline-6-carbonitrile

HRID 1948695Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1948695
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[NH2:10])[C:5]#[N:6].O.[C:12](O)(=O)[CH:13]=[O:14]>Cl>[O:14]=[C:13]1[CH:12]=[N:1][C:2]2[C:9](=[CH:8][CH:7]=[C:4]([C:5]#[N:6])[CH:3]=2)[NH:10]1

Komponenten

4

Edukt 2

HCID 7372853,4-DiaminobenzonitrileHCID 15620607Glyoxylic acid, monohydrate

Produkt 1

HCID 451217302-Hydroxyquinoxaline-6-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

To a stirred solution of 3,4-diaminobenzonitrile (5.00 g, 37.6 mmol) in 5% aq HCl (20 mL) was added glyoxilic acid monohydrate (4.32 g, 46.9 mmol). The mixture was stirred overnight at rt and filtered. The filter cake was washed with water and MeOH to afford 2-oxo-1,2-dihydroquinoxaline-6-carbonitrile as a grey solid which was used directly in the next step.

Aufarbeitung

  1. filtrationfiltered
  2. washThe filter cake was washed with water and MeOH

Quellen und Nachweise

ORD-Eintrag
ord-cad2c461745d40e8b70f6ee8a2236987
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399504B2

Notizen zur Reaktion

Wird geladen…