HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | (3R)-(2-adamantyl) 3-(tert-butoxycarbonylamino)pyrrolidine-1-carboxylate | HCID 52944645 | — |
| Product | (R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt | HCID 67155574 | — |
Reaction Steps
To (3R)-(2-adamantyl) 3-(tert-butoxycarbonylamino)pyrrolidine-1-carboxylate (0.43 g, 1.18 mmol) was added 4 M HCl in dioxane (5 mL, 20 mmol). The mixture was stirred at rt for 1 h and concentrated to afford (R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt (0.45 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399504B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-2f277e339d874a67bc612ea95ef63068 |
| Source note | uspto-grants-2013_03 |