Water → HCID 87146399, compound

Participants

Reaction Steps

To a solution of 2-chloro-8-methylquinoline-3-carboxaldehyde (2.05 g, 10 mmol) in dry THF (20 mL) under nitrogen was added titanium isopropoxide (5.68 g, 20 mmol) and the mixture stirred at r.t. for 10 minutes. (R)-(+)-2-Methyl-2-propanesulfinamide (1.21 g, 10 mmol) was added to the reaction which was stirred at r.t. for 72 h. Water (20 mL) was added and the mixture was extracted with DCM (150 mL). The organic layer was separated, dried (MgSO4), filtered and the solvent removed in vacuo to afford the title compound as a pale yellow solid (2.4 g, 72%). δH (CDCl3) 9.12 (s, 1H), 8.79 (s, 1H), 7.78 (d, J 8.4 Hz, 1H), 7.67 (d, J 6.8 Hz, 1H), 7.51 (t, J 7.8 Hz, 1H), 2.79 (s, 3H), 1.32 (s, 9H). LCMS (ES+) 309, 311 (M+H)+, RT 3.66 minutes (Method 5).

Provenance & Evidence