Acetone → (+)-Pinocembrin

Participants

Reaction Steps

Referring to the preparation method of Example 1, using the mixture of isopropanol and THF (isopropanol:THF=2:1), the mixture of acetonitrile and DMF (acetonitrile:DMF=4:1), the mixture of methanol and acetone (methanol:acetone=3:2), the mixture of ethanol and acetonitrile (ethanol:acetonitrile=1:1), and the mixture of ethanol, acetone and glacial acetic acid (ethanol:acetone:glacial acetic acid=2:1:0.1) as the solvents, white crystalline of pinocembrin was obtained. The results of the experiments were shown in Table 7. Powder X-ray diffraction, DSC and IR analysis were performed on the obtained crystalline, and the results showed that the crystalline form obtained was α crystalline form of pinocembrin.

Provenance & Evidence