2-(Azetidin-1-yl)-5-nitropyridine → 6-(Azetidin-1-yl)pyridin-3-amine

Participants

Reaction Steps

A suspension of 11.5 g (64.18 mmol) of 2-(azetidin-1-yl)-5-nitropyridine, prepared in the previous stage, and of 1 g of Pd/C at 10% in 400 ml of ethanol is stirred vigorously at 20° C. under 5 atmospheres of hydrogen for 4 hours. After this period of time, the mixture is filtered through a celite buffer and then concentrated under reduced pressure. 9.3 g of the expected product are thus obtained, which product is used as it is in the subsequent synthesis.

Provenance & Evidence