Water → 1-(5-Nitropyridin-2-yl)azetidin-3-ol

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.311 g (2.84 mmol) of 3-hydroxyazetidine hydrochloride, 0.3 g (1.89 mmol) of 2-chloro-5-nitropyridine and 0.41 ml (2.84 mmol) of triethylamine in 10 ml of dimethylformamide is heated overnight at 100° C. After this period of time, the suspension is poured into a mixture of 30 ml of water and 30 ml of ethyl acetate. The aqueous phase is separated and then extracted with 20 ml of ethyl acetate. The organic phases are combined, washed three times with 25 ml of water and then dried over sodium sulphate and concentrated under reduced pressure. 0.34 g of the expected product is thus obtained in the form of a solid which will be used as it is in the subsequent synthesis.

Provenance & Evidence