Methanol → HCID 58100944, compound

Participants

Reaction Steps

0.23 g (4.06 mmol) of potassium hydroxide is added to a solution of 0.5 g (1.35 mmol) of ethyl 7-trimethylsilyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate, obtained according to the protocol described in stage 5.2, in 30 ml of a mixture (v/v/v) of methanol, water and dioxane. After stirring at reflux for three hours, the reaction mixture is one-third concentrated under reduced pressure and then taken up in 10 ml of water. The medium is acidified at pH 1 by successive additions of 1N hydrochloric acid. The precipitate is recovered by filtration, washed with water and then dried under reduced pressure. 0.37 g of the expected product is thus isolated, which product is used as it is in the subsequent stage.

Provenance & Evidence