HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 66850251, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-(5-Aminopyridin-2-yl)azetidin-3-ol | HCID 57431525 | — |
| Reactant | HCID 58100944 | HCID 58100944 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66850251 | HCID 66850251 | 12.6% |
Reaction Steps
Compound No. 6 was prepared according to a process similar to that described in stage 5.4, by reacting 0.15 g (0.44 mmol) of 7-trimethylsilyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylic acid, prepared according to the protocol described in stage 5.3, with 109 mg (0.66 mmol) of 3-amino-6-(3-hydroxyazetidin-1-yl)pyridine, prepared according to the protocol described in stage 2.2, in the presence of 87 mg (0.44 mmol) of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDAC) and of 61 mg (0.44 mmol) of 1-hydroxybenzotriazole (HOBT) in 5 ml of dimethylformamide. 27 mg of the expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399491B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-da8310739a334817855f5cbda378fc23 |
| Source note | uspto-grants-2013_03 |